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Showing posts with the label calcineurin inhibitors

How does tacrolimus prograf prevent organ rejection?

Tacrolimus is an active ingredient belonging to the class of immunosuppressants, which subsequently works by suppressing the actions of immune cells and the immune system of the body. It is useful in situations where the body rejects new organs like lungs, liver, or kidneys after an organ transplant. Prograf 1mg capsule is a brand that contains the active compound tacrolimus that delivers a therapeutic effect.  Indications: Prevention of organ rejection in recipients of allogeneic heart, kidney, or liver transplants It can be used along with adrenal corticosteroids in prophylactic treatment approaches in kidney, liver, and lung transplants. Mechanisms involved in preventing organ rejection:  Tacrolimus acts through a cascade of events that involve effective immune suppression. An enzyme called calcineurin is involved in the activation of T cells which is essential for producing basic immune responses against the inflammations. Tacrolimus blocks and inhibits the activity of th...