The Role of mTOR Kinase Inhibitors in Disease Treatment
The mechanistic target of the rapamycin (mTOR) pathway is crucial in regulating cell growth, proliferation, and survival. Dysregulation of this pathway is implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic conditions. mTOR kinase inhibitors have emerged as a vital class of drugs targeting these pathways, offering therapeutic benefits in managing these diseases. This blog delves into the roles of mTOR kinase inhibitors in disease treatment. What is the mTOR metabolic pathway? mTOR Structure and Function: mTOR is a serine/threonine kinase that is a central regulator of cellular metabolism, growth, and survival. It exists in two complexes, mTORC1 and mTORC2, each playing distinct roles in cellular processes. mTORC1: This complex primarily promotes protein synthesis and inhibits autophagy, a process where cells degrade and recycle components. mTORC1 is sensitive to nutrient availability, growth factors, and cellular energy status, making it ...