Mrmed Pharmacy

  Why is EGFR important in cancer patients? EGFR mutations are genetic alterations in the epidermal growth factor receptor (EGFR) gene that lead to uncontrolled cell growth and division. These mutations are found in approximately 10-15% of non-small cell lung cancer (NSCLC) cases, especially among non-smokers and those of Asian descent. Targeted therapies are designed to specifically attack cancer cells with certain mutations, like EGFR while sparing healthy cells. This precision approach leads to better outcomes and fewer side effects compared to traditional chemotherapy. Why EGFR-Mutated NSCLC Requires Specific Treatment? EGFR mutations make NSCLC particularly aggressive and resistant to conventional treatments. Targeted therapies that inhibit the EGFR pathway are crucial in controlling disease progression and improving survival rates. How does osimertinib inhibit EGFR? Third-Generation EGFR Inhibitor: Tagrisso (Osimertinib) is a third-generation EGFR inhibitor specifically desi...

Kinase inhibitors are a type of targeted therapy that can be helpful in the treatment of lung cancer.  Lung cancer often involves genetic mutations that lead to the overactivation of certain signaling pathways, including those mediated by kinases. Kinases are enzymes that regulate various cellular.  processes, including cell growth, division, and survival. By inhibiting specific kinases that are involved in the growth and spread of cancer cells, kinase inhibitors can interfere with the signaling pathways that drive the proliferation of cancer cells. This can help slow down or halt the growth of tumors, making them a valuable treatment option for lung cancer patients. For instance, in lung cancer cases with EGFR mutations, EGFR inhibitors like erlotinib, gefitinib, or osimertinib are used to inhibit the growth of cancer cells by blocking the activity of the mutated EGFR protein. Similarly, ALK inhibitors such as crizotinib or alectinib are employed to target ALK gene rearr...

  Non-Small Cell Lung Cancer (NSCLC) The lungs are two cone-shaped breathing organs located in the chest. As you breathe in, the lungs deliver oxygen into your body. As you exhale, they emit carbon dioxide, a waste product of the body's cells. Each lung is divided into portions known as lobes. The left lung is separated into two lobes. The right lung is slightly larger than the left and has three lobes. Cancer is a disorder in which the body's cells divide abnormally. Lung cancer occurs when cancer begins in the lungs. Lung cancer starts in the lungs and can spread to lymph nodes or other organs. Lung cancer is classified into two types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Non-small cell lung cancer is a disorder in which cancer cells develop in lung tissues and it has many sub types. Smoking is one of the leading causes of non-small cell lung cancer (NSCLC). Types Of Non-Small Cell Lung Cancer (NSCLC) Each type of non-small cell lung cancer h...