Role Of IMDH Inhibitors To Prevent Organ Transplant Rejections
IMDH (Inosine monophosphate dehydrogenase) inhibitors are a class of medications that can be used to prevent organ transplant rejections. Here's an overview of their role and how they work: Background On Organ Transplant Rejection When a person undergoes an organ transplant, such as a kidney, heart, or liver transplant, their immune system recognizes the transplanted organ as foreign tissue. To defend against this perceived threat, the immune system mounts an immune response to destroy the transplanted organ. This process is known as rejection and can lead to the failure of the transplant. Role Of IMDH Inhibitors IMDH inhibitors are a class of immunosuppressive drugs that help prevent organ transplant rejection by suppressing the immune system's activity. These drugs work by interfering with the synthesis of purine nucleotides, which are essential for the proliferation of immune cells, especially T-lymphocytes. Mechanism Of Action IMDH inhibitors primarily target T-lymphocy...