Exploring the Impact of Bevacizumab Injection in Advanced Cancer Treatment

Bevacizumab is a recombinant monoclonal antibody that blocks the growth of new blood vessels (angiogenesis). It is often used in the treatment of various advanced cancers. It is developed to prevent the growth of tumors. It is indicated along with other chemotherapy drugs to treat metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. It is also used to treat cancers of the ovary, fallopian tube, or primary peritoneal cancer. It is not recommended for children under the age of 18.

How Does Bevacizumab work

It is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), which is present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor. As a result, it slows down the rate of progression of cancer.

Uses of Bevacizumab 

Bevacizumab is an anti-cancer medicine and is used for the following conditions which are given below:

  • Glioblastoma multiforme (brain cancer): It has been approved for glioblastoma treatment, a type of brain cancer, in combination with certain chemotherapy regimens.

  • Breast cancer: It is used in combination with chemotherapy to control the spread of breast cancer in metastasis (spreading of cancer cells from one organ to another organ)

  • Metastatic cervical cancer: It is used in combination with chemotherapy in recurrent, persistent, or metastatic cervical cancer and can improve the survival rate of cervical cancer patients.

  • Advanced kidney cancer: Bevacizumab is used along with the interferon for the treatment of metastatic renal cell carcinoma.

  • Metastatic colorectal cancer: It has been shown to improve the overall survival of the patient when used in combination with chemotherapy. 

  • Advanced non-small cell lung cancer: In non-small cell lung cancer (NSCLC), bevacizumab is used in combination with chemotherapy for certain patients, particularly those with advanced or metastatic disease.

  • Liver Cancer (Hepatocellular carcinoma): According to studies, the combination of atezolizumab and bevacizumab drugs gives the best result for treating liver cancer by immunotherapy.

  • Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer: It is also used to treat ovary, fallopian tube, or primary peritoneal cancer in individuals.

Think To Be Consider

Before starting treatment with this medicine, let your doctor know if you have high blood pressure, high blood sugar, stomach disorders, or heart problems. This medicine should not be taken for 28 days before and after surgery as it is associated with poor wound healing and high bleeding complications. It is advised to report to your doctor if you have any dental issues that require surgery before taking this medicine. If you develop any visual changes or confusion, report to your doctor to prevent complications. Individuals who are pregnant and breastfeeding should be cautious while taking the medicine. Before taking the medication, consult with your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or are breastfeeding. Check with your doctor if you have a history of any disease.

Available forms:

Bevacizumab can be available as bevacizumab injections in different dosages. For e.g. Avastin 100mg Injection

Common side effects

  • Numbness in hands or feet

  • Weakness and lack of energy

  • Diarrhea, nausea, vomiting, abdominal pain

  • Constipation

  • Loss of appetite

  • Weight loss

  • Changes in taste and speech

  • Decrease in counts of white blood cells

  • Fever

  • Dry skin

  • Back pain

Conclusion

Bevacizumab plays a major role in the field of anti-cancer, especially in treating the advanced cancer stage. It is effective in improving the life of cancer patients who are in an advanced stage and also improves the survival rate of cancer victims. Research and development are crucial in improving the safety and efficacy of the drug to provide a safe and secure use of the drug with less or negligible side effects. It is crucial to speak with your doctor about the possible side effects of the drug and your previous medical history to use this drug in a safer way.

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